INS and Cognitive impairment: We have previously reported the association of BB-DNA with different phenotypic traits, including free fatty acids levels, leukocyte count, insulin, and glucose levels, in subjects recruited from the general population aged 35 to 75 years old, with plasma BDNF levels in Alzheimer’s affected patients, and with plasma IL-10 and TNF-α levels in mild cognitive impairment subjects [18, 21, 22].