The epithelial-mesenchymal transition of CRC was aided by the decreased MIR22HG.Zhang et al. [27] exhibited TGF-β1 blocked lncRNA transcription in non-homologous end joining pathway 1 (LINP1) in a SMAD4-dependent way, and LINP1 prevented lung cancer cells from engaging in EMT (epithelial–mesenchymal transition), hence regulating cancer cell motility, invasion, and stemness. This evidence concerns the gene CD44 and colorectal carcinoma.