SMAD4 and cancer: The epithelial-mesenchymal transition of CRC was aided by the decreased MIR22HG.Zhang et al. [27] exhibited TGF-β1 blocked lncRNA transcription in non-homologous end joining pathway 1 (LINP1) in a SMAD4-dependent way, and LINP1 prevented lung cancer cells from engaging in EMT (epithelial–mesenchymal transition), hence regulating cancer cell motility, invasion, and stemness.