Previous research has shown that M2-EV inhibits NEDD4L through the transmission of miR-342-3p, thereby suppressing the ubiquitination and degradation of CEP55 by activating the PI3K/AKT/mTOR signaling pathway, which in turn promotes RCC cell growth, migration, and invasion [66]. The gene discussed is AKT1; the disease is renal cell carcinoma.