Finally, H&E staining showed that mice bearing sh-AGAP2-AS1-treated ACHN cells had fewer lung metastasis tumor nodules, while the tumor nodules metastasized to the lung tissue of nude mice bearing sh-AGAP2-AS1 + oe-THBS2-treated ACHN cells increased (Fig. 6G). This evidence concerns the gene THBS2 and neoplasm.