In addition, the lesion IgG + and mucosa IgA + spots exhibited divergent B-cell receptor V/C gene usage, with IGLC2, IGLC3, IGLV3-1, and IGKV4-1 all enriched in the tumor, suggesting a difference in the adaptive response between the two plasma cell types (Fig. 4f). Here, IGLC2 is linked to neoplasm.