In addition, the lack of synaptophysin, AE1/AE3 cytokeratin, S-100 and CD34 expression (Supplementary Fig. 1D-G) ruled out pheochromocytoma, metastatic carcinoma, malignant peripheral nerve sheath tumor, and angiosarcoma, respectively. The gene discussed is CD34; the disease is hereditary pheochromocytoma-paraganglioma.