Hypoxia-induced TGF-β signaling upregulates SLUG and RBFOX2, which in turn transcriptionally repress ESRP1 expression; furthermore, ESRP1 downregulation promotes the generation of the hMENAΔ11a isoform, which results in the mesenchymal phenotype and thereby promotes breast cancer cell invasion [11]. The gene discussed is SNAI2; the disease is breast cancer.