Recurrent somatic mutations in splicing regulators such as splicing factor 3b subunit 1 (SF3B1), serine/arginine-rich splicing factor 2 (SRSF2), U2 small nuclear RNA auxiliary factor 1, and zinc finger CCCH-type, RNA-binding motif and serine/arginine-rich 2 have been detected in several types of hematological malignancies, whereas few mutations have occurred in solid tumors [4, 5]. Here, SF3B1 is linked to hematologic disorder.