A recent study reported that alternative splicing of LRRFIP2 is regulated by ESRP1 and that LRRFIP2 variant 2, which was dominantly expressed in ESRP1-high cells, decreases the metastatic potential of gastric cancer cells in vitro and in vivo, suggesting the involvement of ESRP1 in the metastatic potential of gastric cancer cells by regulating the isoform switching of LRRFIP2 [54]. This evidence concerns the gene ESRP1 and gastric cancer.