A recent study showed that transient receptor potential channel 6 (TRPC6)-mediated calcium entry induces the expression of integrin α6B splice variant by repressing ESRP1, which regulates response to chemotherapy in triple-negative breast cancer cells, indicating the downregulation of ESRP1 by TRPC6-mediated calcium signaling [67]. The gene discussed is TRPC6; the disease is triple-negative breast carcinoma.