The increased viability and nephrogenesis-competency of MM cells may be attributed to the presence of large number of EV proteins involved directly or indirectly in Wnt signaling, VEGF signaling, TGF-beta signaling, PDGF signaling, Notch signaling, integrin signaling, Hh signaling, FGF signaling, EGF signaling, cytoskeleton regulation by Rho GTPase signaling and Cadherin signaling. Here, VEGFA is linked to Miyoshi myopathy.