The univariate logistic regression analysis identified potential risk factors for ASA-AKI, incorporating various factors such as age, BMI, pre-admission CKD status, preoperative estimated glomerular filtration rate, preoperative cystatin C, preoperative white blood cell count (WBC), preoperative sCr, preoperative D-dimer, duration of CPB exceeding 180 min, postoperative drainage volume 24 h after surgery, Cleveland Clinic score, and biomarkers levels (0 h post-surgery), encompassing NGAL, S100A8/A9, PTX3, and CHI3L1. This evidence concerns the gene CHI3L1 and chronic kidney disease.