In the present study with whole genome sequencing, the region is a 79.6 kb common copy number deletion (dbVar ID:nssv15802291, 11:55364273–55,443,871, gnomAD deletion allele frequency 0.27 in Europeans) that spans olfactory receptor family 4 genes (OR4C11, OR4P4, OR4S2, and OR4C6) and was also nominally associated with early obesity (BMI at 15 years of age, β = 0.11, dominant, P = 3.54 × 10− 2) in the ALSPAC cohort. Here, OR4S2 is linked to obesity due to melanocortin 4 receptor deficiency.