Some other significant roles of Nkx2–5 in other tumors include its interactions with Mef2c in ALL, with Notch3 in T cell leukemias, dysregulated Nkx2–5 expression in sarcomas and hypermethylation of Nkx2–5 in breast, prostate and colon cancer [169]. Here, NKX2-5 is linked to acute lymphoblastic leukemia.