Consistent with the known functions of wild‐type p53 in cell death,[24] the inactivation of p53 in mT organoids resulted in increased organoid formation in the organoid survival assay, and promoted PDA progression in vivo (Figure S1C–H, Supporting Information), suggesting that organoid survival phenotype can be served as a translatable readout for the in vivo context. Here, TP53 is linked to Patent ductus arteriosus.