Previously, we showed that TF FOXA1 is capable of activating the transcriptional programs of endoderm lineage through enhancer reprogramming to promote PDA metastasis.[8] Likewise, it is possible that other TFs are also aberrantly regulated in PDA progression and confer aggressive characters through such epigenetic reprogramming, which warrants a further investigation. This evidence concerns the gene TF and Patent ductus arteriosus.