Gene Set Enrichment Analysis (GSEA) of the publicly available expression datasets[26, 29, 30, 31, 32] further revealed that EN1 expression was closely associated with the molecular signatures implicated in aggressiveness of PDA, including epithelial‐mesenchymal transition (EMT) and squamous/basal‐like molecular subtype (Figure 1J–M; Figure S1O, Supporting Information). Here, EN1 is linked to Patent ductus arteriosus.