TF and cancer: During the development, the required cellular processes (e.g., differentiation and death) are tightly regulated by interactions between epigenomes and TF‐mediated lineage‐specific gene programs.[9] Interestingly, the genes involved in neurodevelopmental programs, such as axon guidance pathways, are frequently altered in many cancers, including PDA, leading to the disease progression.[10, 11] It is therefore probable that cancer cells hijack TFs that govern these developmental pathways to confer a survival benefit.