To address this, we previously established an in vitro organoid model derived from Kras+/LSL‐G12D; Trp53+/LSL‐R172H; Pdx1‐Cre (KPC) mouse.[6] The KPC mouse model is considered the standard model to study PDA initiation and progression, which faithfully recapitulates many aspects of the human disease.[7] The organoid models derived from the KPC PDA tissues allowed a direct comparison of the tumor (mT)‐ and paired metastasis (mM)‐derived organoids. The gene discussed is PDX1; the disease is Patent ductus arteriosus.