Programmeddeath‐1 (PD‐1) is a receptor that is primarily expressed on T‐cells and acts to reduce the immune response[24] Tumor cells express a large number of programmed cell death 1 ligand 1 (PD‐L1) on the surface to help tumor cells escape immune surveillance by binding to the PD‐1 receptor on T‐cells[25] Therefore, inhibiting the expression of PD‐L1 in tumor cells is an effective mean to block PD‐1/PD‐L1, thereby reactivating T‐cells to kill tumors. Here, CD274 is linked to neoplasm.