CD274 and neoplasm: Based on the significant influence of epigenetic regulations on tumor immune escape, a “two‐way regulation” epigenetic therapy strategy was first proposed to inhibit tumor immune escape via an integrated nano‐regulator, which can upregulate TAAs expression to improve the immunogenicity and downregulate PD‐L1 expression to block the PD‐1/PD‐L1 immune checkpoint.