The “two‐way regulation” epigenetic therapy strategy via designing an integrated nano‐regulator is proposed to inhibit tumor immune escape, which can upregulate tumor‐associated antigens (TAAs) expression to enhance T‐cell infiltration and downregulate PD‐L1 expression to improve the recognization of T‐cells to tumor cells, thus inhibiting tumor immune escape and activating antitumor immune response. The gene discussed is CD274; the disease is neoplasm.