It is notable that the elevated abundance of Claspin and Bcl-2 was shown in human pancreatic cancer cell lines (PANC-1, SW1990, AsPC-1, and BxPC-3) when compared to those in normal pancreatic cells (HPDE6C) as measured by Western blotting (Fig. 4A). This evidence concerns the gene CLSPN and familial pancreatic carcinoma.