The univariate analysis showed that age (HR = 1.034), female (HR = 0.622), BMI (HR = 1.121), SBP (HR = 1.025), DBP (HR = 1.029), FPG (HR = 5.728), TG (HR = 1.186), LDL-C (HR = 1.244), HDL-C (HR = 0.733), ALT (HR = 1.004), AST (HR = 1.006), BUN (HR = 1.145), Scr (HR = 1.015), ever smoking (HR = 0.894), never smoking (HR = 0.700), ever drinking (HR = 0.784), and never drinking (HR = 0.599) were associated with incident prediabetes (all P < 0.05), family history of diabetes was not associated with prediabetes (P = 0.773). The gene discussed is GPT; the disease is diabetes mellitus.