The multivariate analysis showed that age (HR = 1.020), female (HR = 0.918), BMI (HR = 1.047), SBP (HR = 1.008), DBP (HR = 1.003), FPG (HR = 4.611), TG (HR = 1.067), HDL-C (HR = 1.214), LDL-C (HR = 0.947), ALT (HR = 1.003), BUN (HR = 0.967), and Scr (HR = 1.006) were associated with incident prediabetes (all P < 0.05). This evidence concerns the gene GPT and prediabetes syndrome.