In combination with existing evidence, the current data suggest that TAAR1 agonists, including ulotaront, exert state-specific effects on dopaminergic and glutamatergic neurotransmission, synthesis and/or neuronal firing, which may serve to improve the altered signal-to-noise ratio and presynaptic dopamine dysfunction associated with psychosis. The gene discussed is TAAR1; the disease is psychotic disorder.