The following risk factors were analysed as possible risk factors for development of all s-NPLs and s-MDS/AML and solid tumour separately: age, gender, ECOG and Sanz risk score, fever and coagulopathy, WBC and platelet counts, karyotype t(15;17) vs t(15:17)+others, FLT3-ITD mutation at diagnosis of APL, chemotherapy-based vs chemotherapy free regimens. The gene discussed is FLT3; the disease is acute promyelocytic leukemia.