The following risk factors were analysed as possible risk factors for development of all s-NPLs and s-MDS/AML and solid tumour separately: age, gender, ECOG and Sanz risk score, fever and coagulopathy, WBC and platelet counts, karyotype t(15;17) vs t(15:17)+others, FLT3-ITD mutation at diagnosis of APL, chemotherapy-based vs chemotherapy free regimens. This evidence concerns the gene FLT3 and acute myeloid leukemia.