Utilising in vivo CRISPR and shRNA screening in oncogene expressing mouse embryonic fibroblast in vitro [6] and haematopoietic stem/progenitor cells in vivo [5], respectively, identified the zinc-finger RNA-binding protein ZMAT3 as a critical factor contributing to TRP53-mediated tumour suppression. The gene discussed is ZFR; the disease is neoplasm.