Notably, the most statistically DE genes in Puma−/−p21−/−Zmat3−/− cells included genes that regulate TP53 and compromise its tumour suppression function (Fig. 2G, red arrows), such as Rps2 - regulator of TRP53-MDM2 signalling [16], Klf4 [17], Trb1 [18], Neat1 [19], Cebpb [20], Sik1 [21], Jun [22], Arc [23], and some known TRP53 target genes (Fig. 2G, blue arrows), including Dusp1 [24], Perp [25], Dusp5 [26], Fos [27], Rgs2 [28], Spry1 [29], Plk2 [30] and Zfp36L2 [31]. This evidence concerns the gene PLK2 and neoplasm.