Point-of-care biomarkers commonly utilized in high-resource settings, like C-reactive protein and procalcitonin, have yielded mixed performance in LMIC (e.g., low specificity, poorer performance for bacterial zoonotic pathogens)27,50,55–57, and are potentially affected by higher rates of malnutrition, parasitic disease, HIV, and co-infection58. This evidence concerns the gene CRP and parasitic infectious disease.