It has also been found27 that in a mouse model of melanoma, PD-1 + Tim-3 + CD8+ T acquires its myeloid markers from the surface of antigen-presenting cells by trogocytosis, and is subsequently recognized and killed by T cells, suggesting a higher presence of cells with this phenotype can augment tumor burden and shorten survival time. Here, HAVCR2 is linked to neoplasm.