Further, in the monosodium urate (MSU) induced peritonitis model, the IL-1β release and neutrophil infiltration in the peritoneal lavage were significantly decreased in Kat5fl/fllyz2-Cre mice, as compared to that of in Kat5fl/fl mice (Fig. 6f, g, Supplementary Fig. 8). Here, IL1B is linked to peritonitis.