PITX2 and frontotemporal dementia: Moreover, the mRNA levels of the Wnt/β-catenin targets Cyclin D1 (CCND1), FOS Like 1 (FOSL1) and Paired-like Homeodomain 2 (PITX2) were significantly upregulated in C9ALS/FTD neurons compared with healthy (Fig. 7b) and isogenic (Fig. 7c) control neurons.