To determine whether hepatic Cdo1 is potentially involved in NAFLD pathogenesis, an analysis of the published microarray data generated from the liver tissue of obese mice (GSE83596) and RNA sequencing (RNA-seq) data from the livers of patients (GSE126848) with or without NAFLD in the Gene Expression Omnibus (GEO) database was performed. This evidence concerns the gene CDO1 and metabolic dysfunction-associated steatotic liver disease.