To investigate whether mutant GCase is linked to an altered metabolism leading to neurodevelopmental defects, iPSCs derived from 3 healthy controls (CTRL1, CTRL2, and CTRL3) and 3 GBA-PD patients (PD1, PD2, and PD3) were used to generate midbrain organoid models (Supplementary Table 1). Here, PAF1 is linked to Parkinson disease.