WT1 and neoplasm: Although all tumor samples from patients with pathogenic WT1 germline variants in the current study exhibited 11p15.5 LOH, prior work from our group and others in unilateral Wilms tumor samples demonstrated somatic WT1 pathogenic variants without accompanied 11p15.5 LOH; therefore WT1 pathogenic variants and 11p15.5 LOH often, but not always, accompany one another38,43.