RNF185 and neoplasm: Five genes and/or noncoding RNAs outside the 11p15.5 region were found to have disruption in the normal patterning of allele-specific expression that correlated with tumor 11p15.5 status: RNF185, SNORD116-4, C1QL3, CLEC12A, and NPAS2. RNF185, a gene located at chromosome 22q12.2 that codes for a component of the E3 ubiquitin ligase pathway, was found to have reduction to monoallelic expression in 43.3% of tumor samples with 11p15.5 LOI (FDR p = 0.240) and 35.7% of tumor samples with 11p15.5 LOH (FDR p = 0.041), but 0% of samples with 11p15.5 ROI (Supplementary Table 2).