In two of these three cases, the tumor CTNNB1 variants were distinct (SJWLM066776 CTNNB1 p.T41A vs. p.S45del, SJWLM051028 CTNNB1 p.S45P vs. p.S45del) and in the remaining case (SJWLM066780) the CTNNB1 p.S45F variant was shared in both paired tumors (Fig. 2). Here, CTNNB1 is linked to neoplasm.