TNF and hepatocellular carcinoma: Moreover, the enriched pathways like complement and coagulation cascades, NOD-like receptor signaling pathway, NF-kappa B signaling pathway, Toll-like receptor signaling pathway, TNF signaling pathway, and leukocyte transendothelial migration, indicating that HCC was likely to promote its own development by regulating a variety of receptors or pathways related to immune and inflammatory (Fig. 4c).