Importantly, our previous studies have uncovered its role in hepatocellular carcinoma by regulating endoplasmic reticulum (ER) stress, thereby influencing tumor progression.21 From the therapeutic point of view, it is surprising that the majority of recent studies have failed to note the enormous value of chrysin on HER2-positive breast cancer.22,23 Moreover, no data so far is available regarding the efficacy of pyrotinib combined with chrysin in treating HER2-positive breast cancer. The gene discussed is ERBB2; the disease is breast cancer.