The reactive oxygen species (ROS) generated through ferritinophagy can activate the p53 and PHD2/HIF-1α signaling pathways, while also inhibiting the iron chelator 2,2’-di-pyridylketone hydrazone dithiocarbamate s-butyric acid (DpdtbA), thereby inducing EMT in gastric cancer cells [85]. This evidence concerns the gene TP53 and gastric cancer.