Although the role of post-translational modification in ferroptosis has been gradually emphasized in recent years [42], it has been found that SOCS2-enhanced ubiquitination of SLC7A11 promotes ferroptosis in hepatocellular carcinoma [43], and ubiquitin-specific protease 7 (USP7) promotes ferroptosis via activation of the p53/TFR1 pathway [44], and NEDD4 ubiquitylates VDAC2/3 to suppress erastin-induced ferroptosis in melanoma [45]. The gene discussed is NEDD4; the disease is hepatocellular carcinoma.