Knowing that ferroptosis caused by lipid peroxidation is regulated by the key components of the cysteine-glutamate antiporter known as systemxc- and the antioxidant enzyme glutathione peroxidase 4 (GPX4), we investigated how IM induced ferroptosis and the result showed that the GSH/GSSG ratio was decreased in GIST-T1 and GIST-882 cells treated with IM as compared with those in the untreated cells (Fig. 2A). The gene discussed is GPX4; the disease is gastrointestinal stromal tumor.