Dominantly-inherited mutations in leucine-rich repeat kinase 2 (LRRK2 p.N1437H, p.R1441C/G/H, p.Y1699C, p.G2019S and p.I2020T)3–6 and vacuolar protein sorting 35 (VPS35 p.D620N)7,8 have been genetically linked to parkinsonism that is clinically and pathologically indistinguishable from idiopathic PD2. This evidence concerns the gene LRRK2 and Parkinsonism.