Downstream analysis of signaling pathways revealed a reduced mTOR signaling in both AML cell lines (p-mTOR, p-P70S6K, p-4-EB-P1), reduced ER stress proteins (p-eIF2a) and decreased protein synthesis (Fig. 3E–G, Supplemental Fig. 7). This evidence concerns the gene EIF2A and acute myeloid leukemia.