S100A9 and acute myeloid leukemia: After S100A9-siRNA or tasquinimod treatment for 48 h, the Mito Stress test showed that treated KG-1a and MOLM-13 cells had a significantly lower basal and maximal respiration and ATP-coupled respiration compared to untreated AML cells; all indicative for reduced mitochondrial respiration and mitochondrial respiratory capacity (Fig. 4A–F).