TPM1 and hyperinsulinemic hypoglycemia, familial, 4: The “Tpm1-CM” subpopulation is enriched with transcripts associated with mitochondrial translational termination and elongation (Fig. 6A), and with different metabolic disorders such as tyrosinemia, Reye syndrome, hypermethioninemia, CREST syndrome, and carnitine palmitoyltransferase II deficiency (Fig. 6B).