TLN2 and cardiac hypertrophy: We identified some lncRNAs that are already described in the literature as directly related to heart processes: Mhrt is involved with cardiac hypertrophy and heart failure [36, 37], and also protects cardiomyocytes against H2O2-induced apoptosis [38]; Tln1 is expressed at low levels in normal CMs compared with other cell-types, and combined deletion of CMs Tln1 and Tln2 destabilized the myocardium, leading to heart failure [39].