TPM1 and Other metabolic disease: The “Tpm1-CM” subpopulation is enriched with transcripts associated with mitochondrial translational termination and elongation (Fig. 6A), and with different metabolic disorders such as tyrosinemia, Reye syndrome, hypermethioninemia, CREST syndrome, and carnitine palmitoyltransferase II deficiency (Fig. 6B).