Hand2os1 orchestrates heart development; its locus dampens Hand2 expression to restrain cardiomyocyte proliferation, thereby orchestrating balanced development of cardiac cell lineages [(40)]; Dancr is a lncRNA that has coding potential in the human heart, encoding putative micropeptides and is associated with cardiovascular diseases [41]; Mbnl1 regulates isoproterenol‐induced myocardial remodeling in vitro and in vivo [62]; Meg3 prevents cardiac fibrosis and diastolic dysfunction [2, 62]; AA465934 is associated with early diabetic cardiomyopathy [42]. Here, HAND2 is linked to cardiovascular disorder.