This link between IFNα and reduced production and levels of myeloid cells such as neutrophils not only helps us to better understand the impact of inflammation on the whole hematopoietic compartment, but will also help to understand better the role of IFNα in disease settings such as the autoimmune disease systemic lupus erythematosus in which neutrophil dysfunction plays an integral role in disease pathogenesis (Kaplan, 2011) and IFNα is associated with adverse outcomes (Rönnblom & Leonard, 2019). This evidence concerns the gene IFNA1 and systemic lupus erythematosus.