The main findings of the current study showed that the BNP, TnT, and reduced LVEF were identified as strong predictors of lower survival in patients with chagasic HF with HFrEF (thresholds: BNP > 309 pg/ml, TnT > 27.5 ng/ml, LVEF < 25.5%). The gene discussed is NPPB; the disease is hydrops fetalis.