In the mouse model of Alzheimer’s disease (AD) [11], learning and memory abilities were greatly improved after NGR1 intervention, and further studies revealed that NGR1 could exert neuroprotective effects by increasing the expression of insulin-degrading enzymes and inhibiting the deposition of Aβ, and the underlying mechanism may be related to PPARγ. This evidence concerns the gene RTN4R and early-onset autosomal dominant Alzheimer disease.