In pregnant ewes, administration of potent synthetic glucocorticoids in the last-third pregnancy is known to cause glucose intolerance, insulin insensitivity and/or decreased insulin secretion with increasing age of their offspring (Moss et al. 2001, Sloboda et al. 2002, 2005, 2007, Long et al. 2012). The gene discussed is INS; the disease is Glucose intolerance.