PKM and breast cancer: Advanced stagecancer patients carry a huge number of exosomes in their body fluids,and these exosomes develop complex cell signaling toward cancer development.38 Exosome long noncoding RNA SNHG3 acted as asponge for miRNA-330, favorably regulating pyruvate kinase M1/M2 (PKM),decreasing oxidative phosphorylation, increasing glycolysis, and stimulatingthe proliferation of breast cancer cells.39 Exosomes formed from breast-cancer-derived miRNA-105 can alter themetabolism of CAFs.