This has potentially important implications for molecular testing of preoperative fine needle aspiration, since conventional BRAF-like or RAS-like alterations are commonly absent in oncocytic tumors, while Bethesda category III and IV with oncocytic changes have a higher prevalence of DNA copy-number alterations compared with the same categories without cytologically identified oncocytic morphology [85]. The gene discussed is BRAF; the disease is oncocytic neoplasm.