The circulating levels of 23 cytokines and chemokines (GMCSF, IFNγ, IL10, IL8, CXCL10, CCL2, CCL22, CCL3, CCL4, TNFα, IL15, IL18, CCL8, CXCL9, IL13, IL17, IL1ß, IL4, IL5, IL6, IL1α, TGFβ, VEGF-C) that are highly involved in orchestrating the immune response to cancer were measured in the plasma of patients (n = 21) who received IL12 in three different clinical trials; OSU-9968, OSU-0167, or OSU-11010 and experienced either a PR or CR clinical response, SD or PD following administration of this cytokine (Tables 1 and 2). Here, IL4 is linked to cancer.