After adjusting for confounding by regional volumes and plasma Aβ42/Aβ40, total tau, and NfL, significance inverse regional CVR–MCI risk associations were observed for hippocampus (P = 0.01; Table 3), parahippocampus (P = 0.02), MTG (P = 0.01), ITG (P = 0.048), precuneus (P = 0.02), AG (P = 0.02), FG (P = 0.02), and AD signature composite CVR (P = 0.01). This evidence concerns the gene MAPT and Alzheimer disease.