TNFSF10 and chronic myelogenous leukemia, BCR-ABL1 positive: Raimondo et al. have reported that PDEVs derived from Citrus limon significantly suppressed the growth of tumors and reduced the multiple angiogenesis-related cytokines secretion in chronic myeloid leukemia (CML) through the Tumor necrosis-related apoptosis-inducing ligand (TRAIL) pathway (Raimondo et al., 2015).