Herein, the neuroprotective effects oftwo 8-aminoquinoline–uracil copper complexes were investigatedon the hydrogen peroxide-induced human neuroblastoma SH-SY5Y cells.Both metal complexes markedly restored cell survival, alleviated apoptoticcascades, maintained antioxidant defense, and prevented mitochondrialfunction by upregulating the sirtuin 1 (SIRT1)/3-FOXO3a signalingpathway. The gene discussed is SIRT1; the disease is neuroblastoma.