The univariate logistic regression analysis showed that age (OR = 1.029; 95% CI, 1.013–1.045; p < 0.001), WBC (OR = 1.108; 95% CI, 1.050–1.169; p < 0.001), aspartate aminotransferase (AST) (OR = 1.013; 95% CI, 1.001–1.026; p = 0.037), C reactive proteins (CRP) (OR = 1.014; 95% CI, 1.008–1.020; p < 0.001), and ANA positivity (OR = 0.619; 95% CI, 0.399–0.961; p = 0.033) were associated with the disease severity of COVID-19. This evidence concerns the gene CRP and COVID-19.