In this study, we found that cytokines, including IL32, TNF, CCL2, CCL5, CCL20, CXCL3, CXCL8, and CXCL10, were downregulated by the treatment with TMP269, which demonstrated that TMP269 inhibits inflammation response caused by RABV at an early stage of infection. The gene discussed is CXCL8; the disease is infection.