HDAC1 and schizophrenia: In relation to psychopathology, Bahari-Javan et al., (2017) showed that (i) early life stress (ELS)-induced schizophrenia-like behavioral and synaptic phenotypes in mice were associated with increased expression of histone-deacetylase-1 (Hdac1; one of the epigenetic processes) in PFC, possibly linked to DNA methylation changes (another epigenetic process) and (ii) administration of an HDAC1 inhibitor reversed these schizophrenia-like phenotypes.