In a recent study investigating the molecular organization of human dorsolateral prefrontal cortex (Huuki-Myers et al. 2023), two schizophrenia risk genes, membrane-bound ligand ephrin A5 (EFNA5) and ephrin type-A receptor 5 (EPHA5), were identified to colocalize via cell-cell communication analysis. Here, EPHA5 is linked to schizophrenia.