APPL1 and atherosclerosis: The protein pathway analysis revealed that some of the proteins targeted by the autoantibodies were involved in apoptosis, lipid and atherosclerosis, glycolysis and gluconeogenesis pathways (Figure 3D) and included ENO1, TPI1, GOT1, STK26, CASP6, CASP3, APPL1, HSPD, and IKBKE.