Endothelial nitric oxide synthase, which is expressed in endothelial cells (Fish et al., 2005), produces endogenous gaseous molecules that have been recognized as gasotransmitters, including nitric oxide (NO), which is crucial for vasculogenesis (Förstermann & Sessa, 2012), tumor growth and invasion (Hu et al., 2020; Korde Choudhari et al., 2013), vasodilatation, neurotransmission and macrophage-mediated immunity (Xu et al., 2002). The gene discussed is NOS3; the disease is neoplasm.