MACF1 and premature menopause: Several genes, including GDF9, BMP15, NGF, FANCM, STAG3, FSHR, NRIP1, XPO1, and MACF1, have relevance in the genetic diagnosis, research, and clinical practice of POF (Dixit et al., 2010; Pouresmaeili & Fazeli, 2014).