Several genes, including GDF9, BMP15, NGF, FANCM, STAG3, FSHR, NRIP1, XPO1, and MACF1, have relevance in the genetic diagnosis, research, and clinical practice of POF (Dixit et al., 2010; Pouresmaeili & Fazeli, 2014). This evidence concerns the gene NRIP1 and premature menopause.