Jaillard et al. (2020) identified GDF9, FANCM, STAG3, and FSHR as being involved in POI pathogenesis, and proposed novel associated candidate genes, NRIP1, XPO1, and MACF1, to be further investigated. Fassnacht et al. (2006) conducted a diagnostic analysis in 101 patients with POF, investigating the major candidate genes (DAZL, DBX, FOXL2, INHalpha, GDF9, USP9X) that contribute to POF development. While several transcriptome analyses in POF have been performed (Kuang et al., 2014; Li et al., 2019), a specific molecular diagnostic marker for POF remains elusive. The gene discussed is MACF1; the disease is premature menopause.