Over the past decades, dysregulation of GSK-3β has been linked to the pathogenesis of many disorders, including type 2 diabetes mellitus (T2DM), atherosclerosis, neurodegenerative diseases, and a variety of malignant tumours (Lin et al., 2020; Yang et al., 2021; Zhang et al., 2018). Here, GSK3B is linked to neurodegenerative disease.