GHRL and spontaneous abortion: Indeed, the blockade of Ghrl during pre-implantation, achieved by the treatment with the Ant (D-Lys3)GHRP-6, significantly increased uterine expression of the pro-inflammatory cytokines IL-6 and IL-17, which are embryotoxic and exert anti-trophoblast activities when increased, thus inducing pre-eclampsia and recurrent miscarriage (53, 54).